YC WISDOM PODCAST

Episode transcripts

25 episodes with full transcripts, quotes, and FAQ.

David de Gruijl

Anto

David de Gruijl, founder of the YC F25 company Anto, discusses how the gut microbiome influences how the human body responds to ingested drugs and foods. Anto utilizes trained foun…

Cole Dermott

Locus

Cole Dermott, co-founder of Locus (YC F25) and former Coinbase engineer, discusses his entrepreneurial background and the emerging agentic payments market. He explains that Locus i…

Will Bodewes

Phonely

Will Bodewes, CEO of Phonely and PhD AI researcher, discusses the company's recent 16 million dollar Series A funding round and their ongoing team expansion. He shares insights int…

Wesley Zheng

Wesley Zheng, a founder and Stanford PhD, discusses his entrepreneurial journey in building hardware companies, including Volansi and his current venture, Posh, which tackles energ…

David Kofoed Wind

Agentwork

David Kofoed Wind discusses his entrepreneurial journey from building educational technology companies like Pure Grade and EduFlow to launching his new venture, Agentwork. He share…

Dave Messina

Pioneer Fund

Dave Messina, General Partner at Pioneer Fund and former Human Genome Project researcher, discusses how artificial intelligence and computational biology are transforming healthcar…

Supreet Deshpande

Cintio Labs

Supreet Deshpande, co-founder and CEO of Cintio Labs, discussed his transition from consulting at McKinsey and leading GenAI strategy at JP Morgan to building an AI platform for li…

Vihaar Nandigala

OrangeSlice.ai

Vihaar Nandigala, co-founder of YC Summer 2025 company OrangeSlice.ai, discusses building go-to-market workflows through natural language and the importance of sales functions in s…

Sebastian Fischer

Wardstone

Sebastian Fischer, co-founder and CEO of Wardstone and an alumnus of MIT, NASA, Lockheed Martin, Amazon, and Cruise, discusses his company's mission to build satellites for hyperso…

Magnus Müller

browser-use

Magnus Müller, founder of browser-use from the YC Winter 25 batch, discussed his background in cognitive science and his journey through world travel and hitchhiking. He explained …

Prajwal Prakash

Clueso

Prajwal Prakash, co-founder of Clueso and previously DeskLamp, discusses his entrepreneurial journey from building a PDF reader in college during COVID to joining Y Combinator. He …

Oliver Gunasekara

Impossible Metals

Oliver Gunasekara, CEO of Impossible Metals, discussed his company's mission to harvest critical battery metals from the ocean floor using autonomous underwater robots instead of t…

Tyler Postle

Voker.ai

Tyler Postle, co-founder of YC S24 company Voker.ai, discusses his background in physics and data science, his journey building startups, and how Voker helps businesses integrate L…

Kevin Wu

Leaping AI

Kevin Wu, founder and CEO of Leaping AI, discusses his YC Winter 25 company that builds self-improving voice agents for enterprise call centers. The platform currently handles appr…

Will Bodewes

Phonely

Will Bodewes, CEO of Phonely from Y Combinator's S24 batch, discusses his background as a former PhD student and endurance athlete, and how his company helps businesses build voice…

Ismail Pelaseyed

Superagent

Ismail Pelaseyed, co-founder and CTO of Superagent, discusses building a guided coding platform for product teams to ship AI-generated code into production securely. He shares insi…

Vamsi Saladi

Contour

Vamsi Saladi is the CTO and co-founder of Contour, a YC Summer 2023 company building an AI customer support platform specifically for financial institutions. The company provides a…

Chinmay Bharti

Cod

Chinmay Bharti, co-founder of Cod and a Y Combinator winter '24 participant, discusses his company's mission to help write quality code in production using AI. He shares his backgr…

Gonzalo Espinosa

Double

Gonzalo Espinosa, co-founder of Double and alumnus of Y Combinator's 2023 batch, discusses his extensive entrepreneurial background involving moonshot projects like hyperloop, Tesl…

Ken Book

FluidInvesting.com

Ken Book, CEO of the YC startup FluidInvesting.com, discusses his platform that allows users to invest directly in public company KPIs through futures contracts. He explains the te…

Guillermo Acuña

Koywe

Guillermo Acuña, a founder at Koywe, shares his entrepreneurial journey in building fintech startups in Latin America, including facing regulatory challenges in Chile and transitio…

Sergio Prada

Metal

Sergio Prada, co-founder of Metal and part of the YC winter 2023 batch, discusses his background as a software engineer and his journey through various tech companies. He shares le…

Ben Oladokun

Shekel Mobility

Benjamin Oladokun, co-founder of Y Combinator-backed Shekel Mobility, discusses building a B2B marketplace and financing platform for auto dealers in Africa, specifically focusing …

Alan Zhao

Warmly

Alan Zhao, co-founder of Warmly, discusses his diverse background spanning trading, AI, a Vietnamese restaurant venture, and multiple startups before finding success with Y Combina…

Arvind Veluvali

Fresco

Arvind Veluvali, CEO of the YC-backed construction AI startup Fresco, discusses his journey from studying biology and working at NASA to founding an AI company. In the episode, he …

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